|
KMID : 0352120160310010027
|
|
Journal of Kyung Hee University
2016 Volume.31 No. 1 p.27 ~ p.33
|
|
|
The Efficacy and Appropriate Dosage of Remifentanil as an Adjunct Sedative for Spinal Anesthesia in Elderly Patients
|
|
Lee Soo-Kyung
Chung Jin-Huan
Kim Hyo-Ju
Moon Hyun-Soo
Park Sung-Wook
|
|
|
Abstract
|
|
|
Purpose: Remifentanil may be a useful adjunct for spinal anesthesia because of its titrability and hemodynamic stability. The aim of this study was to determine the appropriate dosage and efficacy of remifentanil as an adjunct in elderly patients under spinal anesthesia.
Methods: Remifentanil 0.5 ㎍/kg was administered 90 seconds before performing spinal anesthesia, followed by continuous infusion with 3 ㎍/kg/hr in 43 elderly patients and the rate was titrated by steps of 0.5 ㎍ /kg/hr at 15-minute intervals as required to achieve an adequate sedation (Observer`s Assessment of Alertness/ Sedation Scale 4). Safety was assessed by respiratory and hemodynamic monitoring.
Results: The mean infusion rate of remifentanil to maintain an adequate sedation without clinically significant adverse event was 3.07±0.79 ㎍/kg/hr. Transient respiratory depression was developed in 29% of patients.
Conclusions: Remifentanil may be a useful adjunct for analgesia-based sedation at a dose of 3.07±0.79 ㎍ /kg/hr in elderly patients under spinal anesthesia. However, frequent occurrence of remifentanil-induced respiratory depression requires careful monitoring and cautious administration.
|
|
|
KEYWORD
|
|
|
Anesthesia, Spinal, Remifentanil
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|